Scrapie.
نویسنده
چکیده
A detailed review is presented of the history, geographical distribution, cause, epidemiology, clinical features, pathogenesis, pathology, diagnosis, prevention, control and economic effects of scrapie in sheep. Brief mention is made of the disease in goats and moufflon. The nature of the agent causing scrapie, the genetic control of the incubation period in sheep and the natural transmission of scrapie in sheep and goats are discussed. National efforts to control scrapie in various countries are outlined.
منابع مشابه
Genotyping of PRNP coding region for scrapie in Indian sheep
Prions are unprecedented infectious pathogens that cause a group of invariably fatal neurodegenerative disease by an entirely novel mechanism. The conformational change in prion proteins results in a change from a predominantly α-helical protein to a β-sheet form, which causes scrapie in sheep and goat. The present study was carried out to identify polymorphisms of the prion protein gene (PrP) ...
متن کاملGlutathione peroxidase (GPX) activity in blood of ewes on farms in different scrapie categories in Iceland
BACKGROUND Preliminary studies indicated decreased glutathione peroxidase (GPX) activity in blood of ewes on scrapie-afflicted farms. Other studies have shown decreased GPX activity in brain of prion-infected mice and in prion-infected cells in vitro. The aim of this study was to examine the GPX activity in blood as well as the distribution of GPX-activity levels from ewes on farms in scrapie-a...
متن کاملIron and iron/manganese ratio in forage from Icelandic sheep farms: relation to scrapie
This study was undertaken in order to examine whether any connection existed between the amounts of iron in forage and the sporadic occurrence of scrapie observed in certain parts of Iceland. As iron and manganese are considered antagonistic in plants, calculation of the Fe/Mn ratios was also included by using results from Mn determination earlier performed in the same samples. Forage samples (...
متن کاملEpidemiological and genetical differences between classical and atypical scrapie cases.
The aim of this study was to analyze the epidemiology and prion protein (PrP) genetics in scrapie-affected sheep flocks in Germany. For this purpose, 224 German scrapie cases in sheep diagnosed between January 2002 and February 2006 were classified as classical or atypical scrapie and the amino acids at codons 136, 141, 154 and 171 were determined. Likewise, representative numbers of flock mate...
متن کاملNorwegian farmers' vigilance in reporting sheep showing scrapie-associated signs
BACKGROUND Scrapie is a chronic neurodegenerative disease affecting small ruminants and belongs to the transmissible spongiform encephalopathies. Scrapie is considered a serious animal disease and it has been notifiable in Norway since 1965. The clinical signs of scrapie might be vague and the farmers, if familiar with the signs of scrapie, are often in the best position for detecting scrapie s...
متن کاملA case-control study of scrapie Nor98 in Norwegian sheep flocks.
Scrapie is a fatal, neurological disease of sheep and goats and belongs to the transmissible spongiform encephalopathies. In 1998, a new type of scrapie, designated scrapie Nor98, was detected in Norway. Scrapie Nor98 differs from classical scrapie in the distribution of pathological changes and of the scrapie prion protein, the Western blot profile of the prion protein, and with isolated cases...
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ورودعنوان ژورنال:
- Revue scientifique et technique
دوره 11 2 شماره
صفحات -
تاریخ انتشار 1992